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NanoInformatics Approaches for Safe-by-Design NanoMaterials (Compsafenano)

Prosjektdetaljer

Webside: https://compsafenano.eu/,

Status: Pågående

Prosjektperiode: 2021–2026

Oppdragsgiver: EU – Horisont Europa (EC/HEU)

Ansvarlig institusjon: NOVAMECHANICS LIMITED

The unique properties of nanomaterials (NMs), relative to their bulk form, has seen them used in a rapidly increasing number of commercial applications. However, with these useful new properties of NMs come potential health and environmental hazards. Thus, as part of a responsible innovation approach, NMs potential risks must be assessed in parallel to exploitation of their benefits.

Due to their enormous variability, NM risk assessment urgently needs advanced in silico methodologies capable of machine learning from limited experimental datasets.

These in silico tools for NMs characterisation, exposure, hazard and risk assessment and sustainability and life cycle assessment, need to support implementation of existing regulatory guidelines and extend regulatory risk assessment to integrate the extensive new knowledge generated computationally.

CompSafeNano’s overarching objective is thus to drive the development of integrated and universally applicable nanoinformatics models, with broad domains of applicability across NMs compositions and forms, that are directly usable by industry, especially SMEs, and regulators for NMs risk assessment and decision making.

CompSafeNano will establish an extended safe-by-design paradigm that includes environmental sustainability (life cycle assessment) based on in silico predictions with experimental testing to validate the results.

CompSafeNano has a clear set of objectives to deliver this vision of an in silico safe-by-design computational platform and will be in close communication with other EU projects to access existing data on NM hazard and integrate existing nanoinformatics and NMs risk governance platforms (i.e. within NanoCommons, NanoSolveIT & RiskGONE). Training activities will benefit both ESRs and ERs from participating organizations, with a strong focus on inter-sectoral exchange (SME-academia) and international collaboration, filling the well-recognised current skills gap in nanoinformatics and big data analytics.

DOI: https://doi.org/10.3030/101008099

Oppdatert: 20.04.2026

NanoInformatics Approaches for Safe-by-Design NanoMaterials har 12 publikasjoner ved NILU:

Application of the Comet Assay in Advanced In Vitro Models

Rundén-Pran, Elise; Yamani, Naouale El; Murugadoss, Sivakumar; Sengupta, Tanima; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Honza, Tatiana; Hudecova, Alexandra Misci; McFadden, Erin; Brochmann, Solveig; Ma, Xiaoxiong; Dusinska, Maria

2026

Challenges and Future Directions in Assessing the Quality and Completeness of Advanced Materials Safety Data for Re-Usability: A Position Paper From the Nanosafety Community

Dumit, Verónica I.; Furxhi, Irini; Nymark, Penny; Afantitis, Antreas; Ammar, Ammar; Amorim, Monica J.B.; Antunes, Dalila; Avramova, Svetlana; Battistelli, Chiara L.; Basei, Gianpietro; Bossa, Cecilia; Cimpan, Emil; Cimpan, Mihaela-Roxana; Ciornii, Dmitri; Costa, Anna; Delpivo, Camilla; Dusinska, Maria; Fonseca, Ana Sofia; Friedrichs, Steffi; Hodoroaba, Vasile Dan; Hristozov, Danail; Isigonis, Panagiotis; Jeliazkova, Nina; Kochev, Nikolay; Kranjc, Eva; Maier, Dieter; Melagraki, Georgia; Papadiamantis, Anastasios G.; Puzyn, Tomasz; Rauscher, Hubert; Reilly, Katie; Jiménez, Araceli Sánchez; Scott-Fordsmand, Janeck J.; Shandilya, Neeraj; Shin, Hyun Kil; Tancheva, Gergana; Rijn, Jeaphianne P.M. van; Willighagen, Egon L.; Wyrzykowska, Ewelina; Bakker, Martine I.; Drobne, Damjana; Exner, Thomas E.; Himly, Martin; Lynch, Iseult

2025

New Approach Methods (NAMs) for genotoxicity assessment of nano- and advanced materials; Advantages and challenges

Gutleb, Arno; Murugadoss, Sivakumar; Stepnik, Maciej; SenGupta, Tanima; Yamani, Naouale El; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Wyrzykowska, Ewelina; Jagiello, Karolina; Judzinska, Beata; Cambier, Sebastien; Honza, Tatiana; McFadden, Erin; Shaposhnikov, Sergey; Puzyn, Tomasz; Serchi, Tommaso; Weber, Pamina; Arnesdotter, Emma; Skakalova, Vier; Jirsova, Katerina; Grudzinski, Ireneusz; Collins, Andrew; Rundén-Pran, Elise; Dusinska, Maria

2025

Thermodynamic and electron paramagnetic resonance descriptors of TiO2 nanoforms interaction with plasma albumin: The interplay between energetic parameters and nanomaterial’s toxicity

Gheorghe, Daniela; Precupas, Aurica; Botea-Petcu, Alina; Sandu, Romica; Teodorescu, Florina; Leonties, Anca Ruxandra; Popa, Vlad Tudor; Matei, Iulia; Ionita, Gabriela; Yamani, Naouale El; Ostermann, Melanie; Sauter, Alexander; Jensen, Keld Alstrup; Cimpan, Mihaela Roxana; Rundén-Pran, Elise; Dusinska, Maria; Tanasescu, Speranta

2025

Thermodynamic and electron paramagnetic resonance descriptors of TiO2 nanoforms interaction with plasma albumin: The interplay between energetic parameters and nanomaterial’s toxicity

Gheorghe, Daniela; Precupas, Aurica; Botea-Petcu, Alina; Sandu, Romica; Teodorescu, Florina; Leonties, Anca Ruxandra; Popa, Vlad Tudor; Matei, Iulia; Ionita, Gabriela; Yamani, Naouale El; Ostermann, Melanie; Sauter, Alexander; Jensen, Keld Astrup; Cimpan, Mihaela Roxana; Runden-Pran, Elise; Dusinska, Maria; Tanasescu, Speranta

2025

Hazard assessment of nanomaterials using in vitro toxicity assays: Guidance on potential assay interferences and mitigating actions to avoid biased results

Yamani, Naouale El; Rundén-Pran, Elise; Varet, Julia; Beus, Maja; Dusinska, Maria; Fessard, Valerie; Moschini, Elisa; Serchi, Tommaso; Cimpan, Mihaela Roxana; Lynch, Iseult; Vrček, ivana Vinković

2024

A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials

Jeliazkova, Nina; Longhin, Eleonora Marta; Yamani, Naouale El; Rundén-Pran, Elise; Moschini, Elisa; Serchi, Tommaso; Vrček, Ivana Vinković; Burgum, Michael J.; Doak, Shareen H.; Cimpan, Mihaela Roxana; Mondragon, Ivan Rios; Cimpan, Emil; Battistelli, Chiara L.; Bossa, Cecilia; Tsekovska, Rositsa; Drobne, Damjana; Novak, Sara; Repar, Neža; Ammar, Ammar; Nymark, Penny; Battista, Veronica Di; Sosnowska, Anita; Puzyn, Tomasz; Kochev, Nikolay; Iliev, Luchesar; Jeliazkov, Vedrin; Reilly, Katie; Lynch, Iseult; Martine, Bakker; Delpivo, Camilla; Jiménez, Araceli Sánchez; Fonseca, Ana Sofia; Manier, Nicolas; Fernandez-Cruz, María Luisa; Rashid, Shahzad; Willighagen, Egon L.; Apostolova, Margarita D; Dusinska, Maria

2024

Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report

Doak, Shareen H.; Andreoli, Cristina; Burgum, Michael J.; Chaudhry, Qasim; Bleeker, Eric; Bossa, Cecilia; Domenech, Josefa; Drobne, Damjana; Fessard, Valérie; Jeliazkova, Nina; Longhin, Eleonora Marta; Rundén-Pran, Elise; Stepnik, Maciej; Yamani, Naouale El; Catalán, Julia; Dusinska, Maria

2023

Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake

Yamani, Naouale El; Rubio, Laura; García-Rodríguez, Alba; Kažimírová, Alena; Rundén-Pran, Elise; Barančoková, Magdaléna; Marcos, Ricard; Dusinska, Maria

2022

An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform

Cheimarios, Nikolaos; Pem, Barbara; Tsoumanis, Andreas; Ilic, Krunoslav; Vrček, Ivana Vinković; Melagraki, Georgia; Bitounis, Dimitrios; Isigonis, Panagiotis; Dusinska, Maria; Lynch, Iseult; Demokritou, Philip; Afantitis, Antreas

2022

CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials

Zouraris, Dimitrios; Mavrogiorgis, Angelos; Tsoumanis, Andreas; Saarimaki, Laura Aliisa; Giudice, Giusy del; Federico, Antonio; Serra, Angela; Greco, Dario; Rouse, Ian; Subbotina, Julia; Lobaskin, Vladimir; Jagiello, Karolina; Ciura, Krzesimir; Judzinska, Beata; Mikolajczyk, Alicja; Sosnowska, Anita; Puzyn, Tomasz; Gulumian, Mary; Wepener, Victor; Martinez, Diego S. T.; Petry, Romana; Yamani, Naouale El; Rundén-Pran, Elise; Murugadoss, Sivakumar; Shaposhnikov, Sergey; Minadakis, Vasileios; Tsiros, Periklis; Sarimveis, Harry; Longhin, Eleonora Marta; Sengupta, Tanima; Olsen, Ann-Karin Hardie; Skakalova, Viera; Hutar, Peter; Dusinska, Maria; Papadiamantis, Anastasios; Gheorghe, L. Cristiana; Reilly, Katie; Brun, Emilie; Ullah, Sami; Cambier, Sebastien; Serchi, Tommaso; Tamm, Kaido; Lorusso, Candida; Dondero, Francesco; Melagrakis, Evangelos; Fraz, Muhammad Moazam; Melagraki, Georgia; Lynch, Iseult; Afantitis, Antreas

2025

Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity

Yamani, Naouale El; Mariussen, Espen; Gromelski, Maciej; Wyrzykowska, Ewelina; Grabarek, Dawid; Puzyn, Tomasz; Tanasescu, Speranta; Dusinska, Maria; Rundén-Pran, Elise

2022