Publikasjoner

Exposure assessment with the urban exposure management tool - case study Oslo.

Lützenkirchen, S.; Laupsa, H.; Fløisand, I.; Bøhler, T.

Exposure modelling related to outdoor air.

Bartonova, A.; Laupsa, H.

Exposure of children to particulate matter in urban areas - model calculations.

Fløisand, I.; Mc Innes, H.; Broday, D.; Lützenkirchen, S.; Holländer, W.; Bartonova, A.

Exposure scenario approach to environmental health problems: two case studies. NILU F

Bartonova, A.; Liu, H.Y.; Loh, M.; ENVIRISK team.

Exposure to oxychlordane is associated with shorter telomeres in arctic breeding kittiwakes.

Blevin, P.; Angelier, F.; Tartu, S.; Ruault, S.; Bustamante, P.; Herzke, D.; Moe, B.; Bech, C.; Gabrielsen, G.W.; Bustnes, J.O.; Chastel, O.

Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator

Sebastiano, Manrico; Angelier, Frédéric; Blévin, Pierre; Ribout, Cécile; Sagerup, Kjetil; Descamps, Sebastien; Herzke, Dorte; Moe, Børge; Barbarud, Christophe; Bustnes, Jan Ove; Gabrielsen, Geir W.; Chastel, Olivier

ExSIRA - Experimental Study to Investigate Risk of selected Amines "Fly me to the moon". NILU F

Velken, A.v.S.

ExSIRA - Experimental study to investigate risk of selected amines (project no. 199874/S60). NILU PP

Berglen, T.F.; ExSIRA project team.

Extending the long-term record of volcanic SO2 emissions with the Ozone Mapping and Profiler Suite nadir mapper.

Carn, S. A.; Yang, K.; Prata, A. J.; Krotkov, N. A.

Extensive reduction of surface UV radiation since 1750 in world's populated regions.

Kvalevåg, M.M.; Myhre, G.; Myhre, C.L.

Extracellular Vesicles as Next-Generation Diagnostics and Advanced Therapy Medicinal Products

Stawarska, Agnieszka; Bamburowicz-Klimkows, Magdalena; Rundén-Pran, Elise; Dusinska, Maria; Cimpan, Mihaela Roxana; Rios Mondragon, Ivan; Grudzinski, Ireneusz P.

Extracellular vesicles (EVs) hold great promise for clinical application as new diagnostic and therapeutic modalities. This paper describes major GMP-based upstream and downstream manufacturing processes for EV large-scale production, also focusing on post-processing technologies such as surface bioengineering and uploading studies to yield novel EV-based diagnostics and advanced therapy medicinal products. This paper also focuses on the quality, safety, and efficacy issues of the bioengineered EV drug candidates before first-in-human studies. Because clinical trials involving extracellular vesicles are on the global rise, this paper encompasses different clinical studies registered on clinical-trial register platforms, with varying levels of advancement, highlighting the growing interest in EV-related clinical programs. Navigating the regulatory affairs of EVs poses real challenges, and obtaining marketing authorization for EV-based medicines remains complex due to the lack of specific regulatory guidelines for such novel products. This paper discusses the state-of-the-art regulatory knowledge to date on EV-based diagnostics and medicinal products, highlighting further research and global regulatory needs for the safe and reliable implementation of bioengineered EVs as diagnostic and therapeutic tools in clinical settings. Post-marketing pharmacovigilance for EV-based medicinal products is also presented, mainly addressing such topics as risk assessment and risk management.

MDPI

Extreme climate of the global troposphere and stratosphere in the 1940-42 related to El Nino.

Brönnimann, S.; Luterbacher, J.; Staehelin, J.; Svendby, T. M.; Hansen, G.; Svenøe, T.

Extreme precipitation event over North China in August 2010: observations, monthly forecasting, and link to intra-seasonal variability of the Silk-Road wave-train across Eurasia.

Orsolini, Y.; Zhang, L.; Peters, D.; Fraedrich, K.