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Fant 10083 publikasjoner. Viser side 404 av 404:

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Physiologically based toxicokinetic models in aggregate exposure: A review

Lamon, L.; Paini, A.; Siccardi, M.; Doyle, J.; McNamara, C.; Galea, K.S.; Ghosh, M.; Louro, H.; Silva, M.J.; Yamani, Naouale El; Dusinska, Maria; Moeller, R.; Duca, R.C.; Cubadda, F.; Viegas, S.; Martins, C.; Price, P.

2025

Developing the chemistry module for 27 fluorinated greenhouse gases (F-gases): Reactions, emissions, and implementation in GEOS-Chem

Li, Yali; Zhu, Lei; Li, Juan; Chen, Yuyang; Western, Luke M.; Young, Dickon; Mühle, Jens; Weiss, Ray F.; Krummel, Paul B.; Lunder, Chris Rene; Liu, Song; Li, Xicheng; Fu, Weitao; Zhang, Peng; Zhang, Xue; Zhang, Jiaming; Wu, Xingyi; Huang, Yuchen; Shen, Huizhong; Ye, Jianhuai; Wang, Chen; Fu, Tzung-May; Yang, Xin

2025

Assessing anthropogenic and natural aerosol sources in the Arctic: A baseline to detect changes due to climate change (AAA-Source)

Becagli, Silvia; Barbaro, Elena; Eckhardt, Sabine; Gilardoni, Stefania; Krejci, Radovan; Mazzola, Mauro; Park, Ki-Tae; Severi, Mirko; Traversi, Rita; Yttri, Karl Espen; Zieger, Paul

2025

Machine learning for mapping glacier surface facies in Svalbard

Wankhede, Sagar F.; Jawak, Shridhar Digambar; Noorudheen, Adeeb H.; Nayak, Akankshya; Thakur, Abhilash; Balakrishna, Keshava; Luis, Alvarinho J.

Glaciers are dynamic and highly sensitive indicators of climate change, necessitating frequent and precise monitoring. As Earth observation technology evolves with advanced sensors and mapping methods, the need for accurate and efficient approaches to monitor glacier changes becomes increasingly important. Glacier Surface Facies (GSF), formed through snow accumulation and ablation, serve as valuable indicators of glacial health. Mapping GSF provides insights into a glacier's annual adaptations. However, satellite-based GSF mapping presents significant challenges in terms of data preprocessing and algorithm selection for accurate feature extraction. This study presents an experiment using very high-resolution (VHR) WorldView-3 satellite data to map GSF on the Midtre Lovénbreen glacier in Svalbard. We applied three machine learning (ML) algorithms—Random Forest (RF), Artificial Neural Network (ANN), and Support Vector Machine (SVM)—to explore the impact of different image preprocessing techniques, including atmospheric corrections, pan sharpening methods, and spectral band combinations. Our results demonstrate that RF outperformed both ANN and SVM, achieving an overall accuracy of 85.02 %. However, nuanced variations were found for specific processing conditions and can be explored for specific applications. This study represents the first clear delineation of ML algorithm performance for GSF mapping under varying preprocessing conditions. The data and findings from this experiment will inform future ML-based studies aimed at understanding glaciological adaptations in a rapidly changing cryosphere, with potential applications in long-term spatiotemporal monitoring of glacier health.

2025

Application of the Comet Assay in Advanced In Vitro Models

Rundén-Pran, Elise; Yamani, Naouale El; Murugadoss, Sivakumar; Sengupta, Tanima; Longhin, Eleonora Marta; Olsen, Ann-Karin Hardie; Honza, Tatiana; Hudecova, Alexandra Misci; McFadden, Erin; Brochmann, Solveig; Ma, Xiaoxiong; Dusinska, Maria

2026

Highly accurate and autonomous programmable platform for providing air pollution data services to drivers and the public – Polish case study

Grochala, Dominik; Paleczek, Anna; Gruszczyński, Sławomir; Wójcikowski, Marek; Pankiewicz, Bogdan; Pietrenko-Dąbrowska, Anna; Kozieł, Sławomir; Cao, Tuan-Vu; Rydosz, Artur

Nitrogen dioxide (NO2) is a well-known air pollutant, mostly elevated by car traffic in cities. To date, small, reliable, cost-efficient multipollutant sensors with sufficient power and accuracy for community-based atmospheric studies are still lacking. The HAPADS (highly accurate and autonomous programmable platforms for providing air pollution data services) platforms, developed and tested in real conditions, can be a possible approach to solving this issue. The developed HAPADS platforms are equipped with three different NO2 sensors (7E4-NO2–5, SGX-7NO2, MICS-2711 MOS) and a combined ambient air temperature, humidity, and pressure sensor (BME280). The platforms were tested during the driving test, which was conducted across various roads, including highways, expressways, and national and regional routes, as well as major cities and the countryside, to analyse the environmental conditions as much as possible (Poland, 2024). The correlation coefficient r was more than 0.8, and RMSE (root mean squared error) was in the 3.3–4.3 μg/m3 range during the calibration process. The results obtained during the driving tests showed R2 of 0.9–1.0, which proves the ability of HAPADS platforms to work in the hard environmental conditions (including high rain and snow, as well as sun and a wide range of temperatures and humidity).

2026

A regulatory perspective on the applicability of NAMs in genotoxicity and carcinogenicity assessment in EU: current practices and future directions

Bossa, Cecilia; Alivernini, Silvia; Andreoli, Cristina; Aquilina, Gabriele; Attias, Leonello; Benfenati, Emilio; Dusinska, Maria; Yamani, Naouale El; Louro, Henriqueta; Marcon, Francesca; Raitano, Giuseppa; Rundén-Pran, Elise; Russo, Maria Teresa; Silva, Maria João; Battistelli, Chiara Laura

New Approach Methodologies (NAMs) are gaining significant momentum globally to reduce animal testing and enhance the efficiency and human relevance of chemical safety assessment. Even with substantial EU commitment from regulatory agencies and the academic community, the full regulatory adoption of NAMs remains a distant prospect. This challenge is further complicated by the fact that the academic world, oriented toward NAMs development, and regulatory agencies, focused on practical application, frequently operate in separate spheres. Addressing this disconnect, the present paper, developed within the European Partnership for the Assessment of Risks from Chemicals (PARC), provides a clear overview of both the available non-animal tests and current evaluation practices for genotoxic and carcinogenic hazard assessment, while simultaneously highlighting existing regulatory needs, gaps, and challenges toward greater human health protection and the replacement of animal testing through NAMs adoption.

The analysis reveals a complex landscape: while the EU is deeply committed to developing and adopting NAMs, as outlined in its Chemical Strategy for Sustainability and supported by initiatives like PARC, prescriptive regulations such as Classification, Labelling and Packaging (CLP) and Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) still heavily mandate in vivo animal data for hazard classification, particularly for germ cell mutagenicity and carcinogenicity. This reliance creates a “too-short-blanket-problem,” where efforts to reduce animal testing may impact human health protection because of the current in vivo-based classification criteria. In contrast, sectors such as cosmetics and certain European Food Safety Authority (EFSA)-regulated products demonstrate greater flexibility toward progressive integration of NAMs. While the deep mechanistic understanding of genotoxicity and carcinogenicity has significantly advanced the integration of alternatives to animal tests into regulatory chemical hazard assessment, their broader and full implementation faces considerable challenges due to both scientific complexities (i.e., the development and validation of fit-for-purpose NAMs) and existing legislative provisions.

2026

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