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An evaluation of the utility of blood concentration of somatic mutagens to inform germ cell mutagenic hazard

Godschalk, Roger; Brauwers, Bente; Chen, Connie L.; Corvi, Raffaella; Dearfield, Kerry L.; Douglas, George R.; Honarvar, Naveed; Kirkland, David; Curieux, Frank Le; Olsen, Ann-Karin Hardie; Pfuhler, Stefan; Stankowski, Leon F.; White, Paul; Benthem, Jan van; Marchetti, Francesco

2026

Evaluating the role of low-cost sensors in machine learning based European PM2.5 monitoring

Shetty, Shobitha; Hassani, Amirhossein; Hamer, Paul David; Stebel, Kerstin; Salamalikis, Vasileios; Berntsen, Terje Koren; Castell, Nuria; Schneider, Philipp

We evaluate the added value of integrating validated Low-Cost Sensor (LCS) data into a Machine Learning (ML) framework for providing surface PM2.5 estimates over Central Europe at 1 km spatial resolution. The synergistic ML-based S-MESH (Satellite and ML-based Estimation of Surface air quality at High resolution) approach is extended, to incorporate LCS data through two strategies: using validated LCS data as a target variable (LCST) and as an input feature via an inverse distance weighted spatial convolution layer (LCSI). Both strategies are implemented within a stacked XGBoost model that ingests satellite-derived aerosol optical depth, meteorological variables, and CAMS (Copernicus Atmospheric Monitoring Service) regional forecasts. Model performance for 2021–2022 is evaluated against a baseline trained on air quality monitoring stations without any form of LCS integration. Our results indicate that the LCSI approach consistently outperforms both the baseline and LCST models, particularly in urban areas, with RMSE reductions of up to 15–20 %. It also exhibits higher accuracy than the CAMS regional interim reanalysis with a lower annual mean absolute error (MAE) of 2.68 μg/m3 compared to 3.32 μg/m3. SHapley Additive exPlanations based analysis indicates that LCSI information improves both spatial and temporal representativeness, with the LCSI strategy better capturing localized pollution dynamics. However, the LCSI's dependency on the spatial LCS layer limits its ability to capture inter-urban pollution transport in regions with sparse or no LCS data. These findings highlight the value of large-scale sensor networks in addressing spatial coverage gaps in official air quality monitoring stations and advancing high-resolution air quality modeling.

2026

A regulatory perspective on the applicability of NAMs in genotoxicity and carcinogenicity assessment in EU: current practices and future directions

Bossa, Cecilia; Alivernini, Silvia; Andreoli, Cristina; Aquilina, Gabriele; Attias, Leonello; Benfenati, Emilio; Dusinska, Maria; Yamani, Naouale El; Louro, Henriqueta; Marcon, Francesca; Raitano, Giuseppa; Rundén-Pran, Elise; Russo, Maria Teresa; Silva, Maria João; Battistelli, Chiara Laura

New Approach Methodologies (NAMs) are gaining significant momentum globally to reduce animal testing and enhance the efficiency and human relevance of chemical safety assessment. Even with substantial EU commitment from regulatory agencies and the academic community, the full regulatory adoption of NAMs remains a distant prospect. This challenge is further complicated by the fact that the academic world, oriented toward NAMs development, and regulatory agencies, focused on practical application, frequently operate in separate spheres. Addressing this disconnect, the present paper, developed within the European Partnership for the Assessment of Risks from Chemicals (PARC), provides a clear overview of both the available non-animal tests and current evaluation practices for genotoxic and carcinogenic hazard assessment, while simultaneously highlighting existing regulatory needs, gaps, and challenges toward greater human health protection and the replacement of animal testing through NAMs adoption.

The analysis reveals a complex landscape: while the EU is deeply committed to developing and adopting NAMs, as outlined in its Chemical Strategy for Sustainability and supported by initiatives like PARC, prescriptive regulations such as Classification, Labelling and Packaging (CLP) and Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) still heavily mandate in vivo animal data for hazard classification, particularly for germ cell mutagenicity and carcinogenicity. This reliance creates a “too-short-blanket-problem,” where efforts to reduce animal testing may impact human health protection because of the current in vivo-based classification criteria. In contrast, sectors such as cosmetics and certain European Food Safety Authority (EFSA)-regulated products demonstrate greater flexibility toward progressive integration of NAMs. While the deep mechanistic understanding of genotoxicity and carcinogenicity has significantly advanced the integration of alternatives to animal tests into regulatory chemical hazard assessment, their broader and full implementation faces considerable challenges due to both scientific complexities (i.e., the development and validation of fit-for-purpose NAMs) and existing legislative provisions.

2026

Highly accurate and autonomous programmable platform for providing air pollution data services to drivers and the public – Polish case study

Grochala, Dominik; Paleczek, Anna; Gruszczyński, Sławomir; Wójcikowski, Marek; Pankiewicz, Bogdan; Pietrenko-Dąbrowska, Anna; Kozieł, Sławomir; Cao, Tuan-Vu; Rydosz, Artur

Nitrogen dioxide (NO2) is a well-known air pollutant, mostly elevated by car traffic in cities. To date, small, reliable, cost-efficient multipollutant sensors with sufficient power and accuracy for community-based atmospheric studies are still lacking. The HAPADS (highly accurate and autonomous programmable platforms for providing air pollution data services) platforms, developed and tested in real conditions, can be a possible approach to solving this issue. The developed HAPADS platforms are equipped with three different NO2 sensors (7E4-NO2–5, SGX-7NO2, MICS-2711 MOS) and a combined ambient air temperature, humidity, and pressure sensor (BME280). The platforms were tested during the driving test, which was conducted across various roads, including highways, expressways, and national and regional routes, as well as major cities and the countryside, to analyse the environmental conditions as much as possible (Poland, 2024). The correlation coefficient r was more than 0.8, and RMSE (root mean squared error) was in the 3.3–4.3 μg/m3 range during the calibration process. The results obtained during the driving tests showed R2 of 0.9–1.0, which proves the ability of HAPADS platforms to work in the hard environmental conditions (including high rain and snow, as well as sun and a wide range of temperatures and humidity).

2026

Corrosion and Soiling in the 21st Century: Insights from ICP Materials and Impact on Cultural Heritage

Tidblad, Johan; Núñez, Alice Moya; Fuente, Daniel de la; Ebell, Gino; Berglen, Tore Flatlandsmo; Grøntoft, Terje; Hans, Ulrik; Christodoulakis, Ioannis; Kajánek, Daniel; Kreislová, Kateřina; Kwiatkowski, Lech; Torreta, Teresa La; Lutze, Rafał; Larrubia, Guadalupe Pinar; Pintus, Valentina; Prange, Michael; Spezzano, Pasquale; Varotsos, Costas; Verney-Carron, Aurélie; Vuorio, Tiina; Yates, Tim

This paper reviews results published by the International Co-operative Programme on Effects on Materials including Historic and Cultural Monuments (ICP Materials) with emphasis on those obtained after the turn of the century. Data from ICP Materials come from two main sources. The first is through exposures of materials and collection of environmental data in a network of atmospheric exposure test sites mainly distributed across Europe. Corrosion of carbon steel has continued to decrease during the period 2000–2020 but corrosion of zinc only up until 2014, and the trend in zinc corrosion is only visible when examining four-year data. Surface recession of limestone as well as soiling of modern glass show no decreasing trend during 2000–2020. The second is through case studies performed at heritage sites across Europe. Risk analysis of corrosion and soiling for twenty-six sites indicate that currently soiling is a more significant maintenance trigger than corrosion. Costs for maintaining heritage sites are substantial and costs attributable to air pollution is estimated from 40% to as much as 80% of the total cost. Future directions of the program are work on effects of particulate matter, improving the scientific basis for the work, and making the monitoring data publicly available.

2025

Microplastic and other anthropogenic particles in surface waters of the Isfjorden system (Svalbard)

Philipp, Carolin; Collard, France; Halsband, Claudia; Herzke, Dorte; Vitale, Giulia; Corami, Fabiana; Husum, Katrine; Gabrielsen, Geir Wing; Hallanger, Ingeborg G.

Knowledge of sources and transport mechanisms of anthropogenic particles (APs) such as microplastics (MPs) and related plastic chemicals, in the Arctic marine environment is limited. This study investigates the surface waters of the Isfjordensystem, where Svalbard's largest settlement, Longyearbyen, is located, for the presence of APs. The wastewater from Longyearbyen is released untreated into Adventfjorden, which is a branch of Isfjorden. Samples from the inflowing current of Isfjorden into Adventfjorden, and its outflowing current were sampled and analyzed for APs (>50 μm). APs were classified regarding size, shape, and polymer type via μFTIR spectroscopy. Each location showed an AP burden (Isfjorden: 26 APs/L, Adventfjorden: 20 APs/L). Highest amounts of APs were found in the Isfjorden current (37 APs/L), before entering Adventfjorden. 14 APs/L were indicated near the wastewater effluent in Adventfjorden, and 15 APs/L in the outflowing current in Isfjorden. Plastic related chemicals, polypropylene and other polyolefins had high frequencies, but silk and rayon material dominated each location except the inflowing current from Isfjorden. Local sources like wastewater and other anthropogenic activities, as well as northwards long-range transport from the south into the Arctic, are considered. Oceanographic dynamics, and the time of sampling seems to affect the distribution of APs in the surface waters, besides its characteristics itself (e.g., polymer type and size).

2025

Construction of an enterprise-level global supply chain database

Katafuchi, Yuya; Li, Xinmeng; Moran, Daniel; Yamada, Taiki; Fujii, Hidemichi; Kanemoto, Keiichiro

Data tracing global supply chains, commonly captured in input–output models, is a foundational resource across economic, regulatory, investment, defense, and environmental applications. Such models provide insight into interdependency and environmental burden-shifting, forming part of the empirical basis for policies such as Scope 3 embodied emissions targets, supply chain transparency, life cycle assessments, and product declarations. Current approaches, based on national statistics, remain constrained by sector-level resolution, limiting their precision and utility in certain applications. Here, we document the construction of an enterprise-level multi-regional input–output (EMRIO) table. This database merges official national input–output tables with publicly available firm-level production and transaction data, creating a globally consistent account of purchases and sales across 9,466 companies, 86,305 subsegments, and 121 countries. The finer resolution allows supply chain transactions to be represented in greater detail, providing an additional resource for analyses and policy tools requiring more disaggregated supply chain information.

2025

Monitoring and volatile organic compounds characterization (isoprene, monoterpene and BTEX) in a tropical-oceanic environment in Reunion island (Indian ocean, south hemisphere)

Magand, Olivier; Boulanger, Patricia; Staménoff, Pierre; David, Magali; Hernandez, Patrick; Golubic, Eric; Hello, Yann; Ah-Peng, Claudine; Duflot, Valentin; Ktata, Olivier; Rocco, Manon

2025

Impact of leakage during HFC-125 production on the increase in HCFC-123 and HCFC-124 emissions

Western, Luke M.; Bourguet, Stephen; Crotwell, Molly; Hu, Lei; Krummel, Paul B.; Longueville, Hélène De; Manning, Alistair J.; Mühle, Jens; Rust, Dominique; Vimont, Isaac; Vollmer, Martin K.; An, Minde; Arduini, Jgor; Engel, Andreas; Fraser, Paul J.; Ganesan, Anita L.; Harth, Christina M.; Lunder, Chris Rene; Maione, Michela; Montzka, Stephen A.; Nance, David; O'Doherty, Simon; Park, Sunyoung; Reimann, Stefan; Salameh, Peter K.; Schmidt, Roland; Stanley, Kieran M.; Wagenhäuser, Thomas; Young, Dickon; Rigby, Matt; Prinn, Ronald G.; Weiss, Ray F.

Hydrochlorofluorocarbons (HCFCs) are ozone-depleting substances whose production and consumption have been phased out under the Montreal Protocol in non-Article 5 (mainly developed) countries and are currently being phased out in the rest of the world. Here, we focus on two HCFCs, HCFC-123 and HCFC-124, whose emissions are not decreasing globally in line with their phase-out. We present the first measurement-derived estimates of global HCFC-123 emissions (1993–2023) and updated HCFC-124 emissions for 1978–2023. Around 5 Gg yr−1 of HCFC-123 and 3 Gg yr−1 of HCFC-124 were emitted in 2023. Both HCFC-123 and HCFC-124 are intermediates in the production of HFC-125, a non-ozone-depleting hydrofluorocarbon (HFC) that has replaced ozone-depleting substances in many applications. We show that it is possible that the observed global increase in HCFC-124 emissions could be entirely due to leakage from the production of HFC-125, provided that its leakage rate is around 1 % by mass of HFC-125 production. Global emissions of HCFC-123 have not decreased despite its phase-out for production under the Montreal Protocol, and its use in HFC-125 production may be a contributing factor to this. Emissions of HCFC-124 from western Europe, the USA and East Asia have either fallen or not increased since 2015 and together cannot explain the entire increase in the derived global emissions of HCFC-124. These findings add to the growing evidence that emissions of some ozone-depleting substances are increasing due to leakage and improper destruction during fluorochemical production.

2025

Machine learning for mapping glacier surface facies in Svalbard

Wankhede, Sagar F.; Jawak, Shridhar Digambar; Noorudheen, Adeeb H.; Nayak, Akankshya; Thakur, Abhilash; Balakrishna, Keshava; Luis, Alvarinho J.

Glaciers are dynamic and highly sensitive indicators of climate change, necessitating frequent and precise monitoring. As Earth observation technology evolves with advanced sensors and mapping methods, the need for accurate and efficient approaches to monitor glacier changes becomes increasingly important. Glacier Surface Facies (GSF), formed through snow accumulation and ablation, serve as valuable indicators of glacial health. Mapping GSF provides insights into a glacier's annual adaptations. However, satellite-based GSF mapping presents significant challenges in terms of data preprocessing and algorithm selection for accurate feature extraction. This study presents an experiment using very high-resolution (VHR) WorldView-3 satellite data to map GSF on the Midtre Lovénbreen glacier in Svalbard. We applied three machine learning (ML) algorithms—Random Forest (RF), Artificial Neural Network (ANN), and Support Vector Machine (SVM)—to explore the impact of different image preprocessing techniques, including atmospheric corrections, pan sharpening methods, and spectral band combinations. Our results demonstrate that RF outperformed both ANN and SVM, achieving an overall accuracy of 85.02 %. However, nuanced variations were found for specific processing conditions and can be explored for specific applications. This study represents the first clear delineation of ML algorithm performance for GSF mapping under varying preprocessing conditions. The data and findings from this experiment will inform future ML-based studies aimed at understanding glaciological adaptations in a rapidly changing cryosphere, with potential applications in long-term spatiotemporal monitoring of glacier health.

2025

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