Publikasjoner

Comet in Germ Cells = CIG

Olsen, Ann-Karin Hardie

Combining plasma measurements and mechanistic modeling to explore the effect of POPs on type 2 diabetes mellitus in Norwegian women.

Rylander, C.; Sandanger, T.M.; Nøst, T.H.; Breivik, K.; Lund, E.

Combining in vitro toxicity data with QSARs and mass balance exposure models for high throughput risk assessment.

Arnot, J.; Brown, T.; Breivik, K.; Thomas, R.; Wetmore, B.

Combining Advanced Analytical Methodologies to Uncover Suspect PFAS and Fluorinated Pharmaceutical Contributions to Extractable Organic Fluorine in Human Serum (Tromsø Study)

Cioni, Lara; Nikiforov, Vladimir; Benskin, Jonathan P.; Coelho, Ana Carolina; Dudášová, Silvia; Lauria, Melanie; Lechtenfeld, Oliver J.; Plassmann, Merle M.; Reemtsma, Thorsten; Sandanger, Torkjel Manning; Herzke, Dorte

A growing number of studies have reported that routinely monitored per- and polyfluoroalkyl substances (PFAS) are not sufficient to explain the extractable organic fluorine (EOF) measured in human blood. In this study, we address this gap by screening pooled human serum collected over 3 decades (1986–2015) in Tromsø (Norway) for >5000 PFAS and >300 fluorinated pharmaceuticals. We combined multiple analytical techniques (direct infusion Fourier transform ion cyclotron resonance mass spectrometry, liquid chromatography-Orbitrap-high-resolution mass spectrometry, and total oxidizable precursors assay) in a three-step suspect screening process which aimed at unequivocal suspect identification. This approach uncovered the presence of one PFAS and eight fluorinated pharmaceuticals (including some metabolites) in human serum. While the PFAS suspect only accounted for 2–4% of the EOF, fluorinated pharmaceuticals accounted for 0–63% of the EOF, and their contribution increased in recent years. Although fluorinated pharmaceuticals often contain only 1–3 fluorine atoms, our results indicate that they can contribute significantly to the EOF. Indeed, the contribution from fluorinated pharmaceuticals allowed us to close the organofluorine mass balance in pooled serum from 2015, indicating a good understanding of organofluorine compounds in humans. However, a portion of the EOF in human serum from 1986 and 2007 still remained unexplained.

Combined observational and modeling based study of the aerosol indirect effect.

Storelvmo, T.; Kristjánsson, J.E.; Myhre, G.; Johnsrud, M.; Stordal, F.

Combined data assimilation of ozone tropospheric columns and stratospheric profiles in a high-resolution CTM.

Barré, J.; Peuch, V.-H.; Lahoz, W. A.; Attié, J.-L.; Josse, B.; Piacentini, A.; Eremenko, M.; Dufour, G.; Nedelec, P.; von Clarmann, T.; El Amraoui, L.

Combined characterisation of GOME and TOMS total ozone measurements from space using ground-based observations from the NDSC .

Lambert, J.C.; Van Roozendael, M.; Simon, P.C.; Pommereau, J.P.; Goutail, F.; Gleason, J.F.; Andersen, S.B.; Arlander, D.W.; Van, N.A.B.; Claude, H.; de la Noe, J.; De Maziere, M.; Dorokhov, V.; Eriksen, P.; Green, A.; Tørnkvist, K.K.; Høiskar, B.A.K.; Kyro, E.; Leveau, J.; Merienne, M.F.; Milinevsky, G.; Roscoe, H.K.; Sarkissian, A.; Shanklin, J.D.; Stahelin, J.; Tellefsen, C.W.; Vaughan, G.

Columnar aerosol properties seen at the Antarctic Troll station (72.0S, 2.3E) since 2007. NILU PP

Stebel, K.; Fiebig, M.; Wasseng, J.; Lunder, C.; Hansen, G.; Wehrli, C.

Collective online platforms for financial and environmental awareness. Lecture Notes in Computer Science, Vol. 10078

Satsiou, A.; Panos, G.; Praggidis, I.; Vrochidis, S.; Papadopoulos, S.; Keratidis, C.; Syropoulou, P.; Liu, H.-Y. (eds.)

Collective awareness platform for outdoor air pollution - the hackAIR approach.

Grossberndt, S.; Liu, H.-Y.

Collection and storage of human white blood cells for analysis of DNA damage and repair activity using the comet assay in molecular epidemiology studies

Møller, Peter; Bankoglu, Ezgi Eyluel; Stopper, Helga; Giovannelli, Lisa; Ladeira, Carina; Koppen, Gudrun; Gajski, Goran; Collins, Andrew Richard; Valdiglesias, Vanessa; Laffon, Blanca; Boutet-Robinet, Elisa; Perdry, Hervé; Del Bo, Cristian; Langie, Sabine A.S.; Dusinska, Maria; Azqueta, Amaya

DNA damage and repair activity are often assessed in blood samples from humans in different types of molecular epidemiology studies. However, it is not always feasible to analyse the s#38les on the day of collection without any type of storage. For instance, certain studies use repeated sampling of cells from the same subject or samples from different subjects collected at different time-points, and it is desirable to analyse all these samples in the same comet assay experiment. In addition, flawless comet assay analyses on frozen samples opens up for the possibility of using this technique on biobank material. In this article we discuss the use of cryopreserved peripheral blood mononuclear cells (PBMCs), buffy coat (BC) and whole blood (WB) for analysis of DNA damage and repair using the comet assay. The published literature and the authors’ experiences indicate that various types of blood samples can be cryopreserved with only minor effect on the basal level of DNA damage. There is evidence to suggest that WB and PBMCs can be cryopreserved for several years without much effect on the level of DNA damage. However, care should be taken when cryopreserving WB and BCs. It is possible to use either fresh or frozen samples of blood cells, but results from fresh and frozen cells should not be used in the same dataset. The article outlines detailed protocols for the cryopreservation of PBMCs, BCs and WB samples.

Oxford University Press

Coherent turbulent structures across a vegetation discontinuity.

Huang, J.; Cassiani, M.; Albertson, J.D.

Coffee and oxidative stress: a human intervention study

Shaposhnikov, Sergey; Hatzold, Thomas; El Yamani, Naouale; Stavro, Philip Mark; Lorenzo, Yolanda; Dusinska, Maria; Reus, Astrid; Pasman, Wilrike J.; Collins, Andrew Richard