Fant 10468 publikasjoner. Viser side 144 av 419:
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2014
In order to measure progress towards the aims outlined by the United Nations (UN) 2030 Agenda, data are needed for the different indicators that are linked to each UN Sustainable Development Goal (SDG). Where statistical or scientific data are not sufficient or available, alternative data sources, such as data from citizen science (CS) activities, could be used.
Statistics Norway, together with the Norwegian Association of Local and Regional Authorities, have developed a taxonomy for classifying indicators that are intended to measure the SDGs. The purpose of this taxonomy is to sort, evaluate, and compare different SDG indicators and to assess their usefulness by identifying their central properties and characteristics. This is done by organizing central characteristics under the three dimensions of Goal, Perspective, and Quality. The taxonomy is designed in a way that can help users to find the right indicators across sectors to measure progress towards the SDGs depending on their own context and strategic priorities. The Norwegian taxonomy also offers new opportunities for the re-use of data collected through CS activities. This paper presents the taxonomy and demonstrates how it can be applied for an indicator based on a CS data set, and we also suggest further use of CS data.
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Organ-specific in vitro models for prediction of hazard assessment of nanomaterials
Organ-specific multicellular in vitro models are used to mimic the lung-blood-brain axis, and to assess the nanomaterials (NMs) safety in humans. We employed a triculture lung model, a whole-blood model, an astrocytes-neurons coculture to examine health outcomes by three cerium dioxide (CeO2) NMs and silver (Ag) nanowires. Endpoints included cytotoxicity, gene expression, genotoxicity, inflammatory markers at the air–liquid interface (ALI), complement activation, and secondary toxicity in astrocytes-neurons coculture. Post-exposure, CeO2–3.5 nm high-dose decreased cell viability, no DNA damage was detected. At epithelial-macrophages interface, CeO2–50 nm upregulated surfactant protein A (SPA), cell surface death receptor (FAS), and heme oxygenase-1 (HMOX1), whereas CeO2–3.5 nm downregulated SPA. Ag-nanowires upregulated HMOX1, macrophage inflammatory protein-1β (MIP-1β), granulocyte colony-stimulator factor (G-CSF), chemokine C-X-C-motif ligand 1 (CXCL1). At endothelial side, CeO2–50 nm and − 3.5 nm, and Ag-nanowires upregulated HMOX1. In whole-blood model, CeO2–3.5 nm high-dose reduced terminal complement complex (TCC) proteins, while CeO2–50 nm and Ag-nanowires increased them. Nanomaterials activated CD11b+ on granulocytes and monocytes. Ag-nanowires conditioned-medium (CM) on astrocytes-neurons coculture, decreased cell viability. CeO2–50 nm CM upregulated IL1β, NFκB, and HMOX1. Overall, CeO₂–3.5 nm exhibits lung toxicity; CeO₂–50 nm CM triggers inflammatory response and Ag-nanowires CM may induce cytotoxicity in brain cells.
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