Fant 9855 publikasjoner. Viser side 86 av 395:
2010
Genotoxicity testing for nanomaterials remains challenging as standard testing approaches require some adaptation, and further development of nano-specific OECD Test Guidelines (TGs) and Guidance Documents (GDs) are needed. However, the field of genotoxicology continues to progress and new approach methodologies (NAMs) are being developed that could provide relevant information on the range of mechanisms of genotoxic action that may be imparted by nanomaterials. There is a recognition of the need for implementation of new and/or adapted OECD TGs, new OECD GDs, and utilization of NAMs within a genotoxicity testing framework for nanomaterials. As such, the requirements to apply new experimental approaches and data for genotoxicity assessment of nanomaterials in a regulatory context is neither clear, nor used in practice. Thus, an international workshop with representatives from regulatory agencies, industry, government, and academic scientists was convened to discuss these issues. The expert discussion highlighted the current deficiencies that exist in standard testing approaches within exposure regimes, insufficient physicochemical characterization, lack of demonstration of cell or tissue uptake and internalization, and limitations in the coverage of genotoxic modes of action. Regarding the latter aspect, a consensus was reached on the importance of using NAMs to support the genotoxicity assessment of nanomaterials. Also highlighted was the need for close engagement between scientists and regulators to (i) provide clarity on the regulatory needs, (ii) improve the acceptance and use of NAM-generated data, and (iii) define how NAMs may be used as part of weight of evidence approaches for use in regulatory risk assessments.
Oxford University Press
2023
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2020
Cyclic volatile methyl siloxanes in the terrestrial and aquatic environment at remote Arctic sites
Cyclic volatile methyl siloxanes (cVMS) are widely used chemicals with high emissions to the atmosphere due to their volatility. They are found in the Arctic atmosphere, indicating potential for long-range transport. This study examined the potential for deposition of cVMS (D4, D5, D6) to surface media via snow in Arctic regions. Results showed low cVMS levels in vegetation, soil, sediment, and marine biota. D4 was detected above detection limits but generally below quantification limits, while D5 and D6 were generally not detected. This aligns with current research, suggesting negligible cVMS input from atmospheric deposition via snow and snow melt.
NILU
2025
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CZ0049 - Activity 2. Implementation of a secondary aerosol module in the CAMx model. NILU TR
Prosjekt CZ0049 har som mål å bedre vår kunnskap og karakteristikk av PM, spesielt dannelse og identifisering av sekundære organiske aerosoler. Rapporten beskriver resultater fra aktivitet 2 "Implementering av en Sekundær Organisk Aerosol modul i CAMx". Vi har studert SOA reaksjonskammereksperimenter fra litteraturen og generert en oppdatert parameterisering av antropogen SOA dannelse. Den nye parameteriseringen er implementert i kjemitransportmodellen CAMx. Kildekode og detaljert arbeidsbeskrivelse er inkludert i rapporten.
2010