Publikasjoner

DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population

Niazi, Yasmeen; Thomsen, Hauke; Smolkova, Bozena; Vodickova, Ludmila; Vodenkova, Sona; Kroupa, Michal; Vymetalkova, Veronika; Kazimirova, Alena; Barancokova, Magdalena; Volkovova, Katarina; Staruchova, Marta; Hoffmann, Per; Nöthen, Markus M; Dusinska, Maria; Musak, Ludovit; Vodicka, Pavel; Försti, Asta; Hemminki, Kari

Elsevier

Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

Gupta, Suchi Smita; Singh, Krishna P.; Gupta, Shailendra; Dusinska, Maria; Rahman, Qamar

During the last two decades several nanoscale materials were engineered for industrial and medical applications. Among them carbon nanotubes (CNTs) are the most exploited nanomaterials with global production of around 1000 tons/year. Besides several commercial benefits of CNTs, the fiber-like structures and their bio-persistency in lung tissues raise serious concerns about the possible adverse human health effects resembling those of asbestos fibers. In this review, we present a comparative analysis between CNTs and asbestos fibers using the following four parameters: (1) fibrous needle-like shape, (2) bio-persistent nature, (3) high surface to volume ratio and (4) capacity to adsorb toxicants/pollutants on the surface. We also compare mechanisms underlying the toxicity caused by certain diameters and lengths of CNTs and asbestos fibers using downstream pathways associated with altered gene expression data from both asbestos and CNT exposure. Our results suggest that indeed certain types of CNTs are emulating asbestos fiber as far as associated toxicity is concerned.

MDPI

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Azqueta, Amaya ; Stopper, Helga; Zegura, Bojana; Dusinska, Maria; Møller, Peter

The comet assay is used to measure DNA damage induced by chemical and physical agents. High concentrations of test agents may cause cytotoxicity or cell death, which may give rise to false positive results in the comet assay. Systematic studies on genotoxins and cytotoxins (i.e. non-genotoxic poisons) have attempted to establish a threshold of cytotoxicity or cell death by which DNA damage results measured by the comet assay could be regarded as a false positive result. Thresholds of cytotoxicity/cell death range from 20% to 50% in various publications. Curiously, a survey of the latest literature on comet assay results from cell culture studies suggests that one-third of publications did not assess cytotoxicity or cell death. We recommend that it should be mandatory to include results from at least one type of assay on cytotoxicity, cell death or cell proliferation in publications on comet assay results. A combination of cytotoxicity (or cell death) and proliferation (or colony forming efficiency assay) is preferable in actively proliferating cells because it covers more mechanisms of action. Applying a general threshold of cytotoxicity/cell death to all types of agents may not be applicable; however, 25% compared to the concurrent negative control seems to be a good starting value to avoid false positive comet assay results. Further research is needed to establish a threshold value to distinguish between true and potentially false positive genotoxic effects detected by the comet assay.

Do perfluorinated compounds in dust from Norwegian houses affect the serum levels of their residents?

Haug, L.S.; Huber, S.; Schlabach, M.; Becher, G.; Thomsen, C.

Do physiography and hydrology determine the physico-chemical properties and trophic status of coastal lagoons? A comparative approach.

Roselli, L.; Cañedo-Argüelles, M.; Costa Goela, P.; Cristina, S.; Rieradevall, M.; D'Adamo, R.; Newton, A.,.

Do we need to include pheromone and kairomone disruption in environmental risk assessments of chemicals? NILU F

Kylin, H.

Do we need to include pheromone and kairomone disruption in environmental risk assessments of chemicals? NILU F

Kylin, H.

Does climate change and seasons have an influence the accumulation of contaminants in Arctic marine pelagic food webs?

Hallanger, I.G.; Ruus, A.; Warner, N.A.; Evenset, A.; Gabrielsen, G.W.; Borgå, K.

Does dimethyl sulphide produce new cloud condensation nuclei over the central Arctic Ocean?

Karl, M.; Gross, A.; Leck, C.; Pirjola, L.

Does PTFE Degrade at High Pressure in the Deep Ocean? a Model Process Observed in a Common LC-Pump

Nikiforov, Vladimir

Does the SPE of January 2005 produce a unique, identifiable signature in polar middle atmosphere dynamics?

Kishore, K.; Tissøy, H.; Orsolini, Y.J.; Singer, W.

Domestic heating: an important source of air pollution in European urban areas.

Guerreiro, C.; de Leeuw, F.; Horalek, J.; Viana, M.

Domestic heating: an important source of particulate matter pollution.

Guerreiro, C.; de Leeuw, F.; Horálek, J.; Viana, M.