Fant 9885 publikasjoner. Viser side 160 av 396:
HENVINET. Evaluation questionnaire - causal chain for nanoparticles. NILU TR
The HENVINET consortium has developed a questionnaire to identify knowledge gaps in the state of the art in scientific knowledge. Literature reviews covered all elements that compose the causal chain of the different environmental health issues from emissions to exposures, to effects and to health impacts. Ultimately, the aim is to discuss the implications of these for policy and research.
In this evaluation we focus on effect of nanoparticles on various environmental processes and their impact on human health. The questionnaire consists of two separate parts. In Part A, you will be asked to comment on the completeness and structure of a diagram illustrating our current understanding of the cause-effect relationship of intentional and unintentional nanoparticles on environment and their subsequent impact on human health. In Part B, you will be asked to express your level of confidence in scientists' ability to predict the magnitude of a disease burden that is expected to occeur as a result of release of nanoparticles in the environment.
2010
HENVINET. Evaluation questionnaire - causal chain for phthalates. NILU TR
The HENVINET consortium has developed a questionnaire to identify knowledge gaps in the state of the art in scientific knowledge. Literature reviews covered all elements that compose the causal chain of the different environmental health issues from emissions to exposures, to effects and to health impacts. Ultimately, the aim is to discuss the implications of these for policy and research.
In this evaluation we focus on the cause¿effect relationship between phthalates in the environment and endocrine disruption in humans. The questionnaire consists of two separate parts. In Part A, you will be asked to comments on the completeness and structure of a diagram illustrating our current understanding of the cause¿effect relationship. In Part B, you will be asked
to express your level of confidence in the scientists¿ ability to predict the magnitude of a variety of effects of phthalates in the environment.
2010
HENVINET. Evaluation questionnaire - climate change and respiratory diseases. NILU TR
The HENVINET consortium has developed a questionnaire to identify knowledge gaps in the state of the art in scientific knowledge. Literature reviews covered all elements that compose the causal chain of the different environmental health issues from emissions to exposures, to effects and to health impacts. Ultimately, the aim is to discuss the implications of these for policy and research.
In this evaluation we focus on various aspects of the cause¿effect relationship between climate change and asthma/allergy and other respiratory diseases. The questionnaire consists of two separate parts. In Part A, you will be asked to comments on the completeness and structure of a diagram illustrating our current understanding of the cause¿effect relationship. In Part B,
you will be asked to express your level of confidence in the claims that specific effects are expected to occur, at least in some regions, as a result of climate change.
2010
HENVINET. Evaluation questionnaire - traffic pollution and environmental health. NILU TR
The HENVINET consortium has developed a questionnaire to identify knowledge gaps in the state of the art in scientific knowledge. Literature reviews covered all elements that compose the causal chain of the different environmental health issues from emissions to exposures, to effects and to health impacts. Ultimately, the aim is to discuss the implications of these for policy and research.
In this evaluation we focus on various aspects of the cause¿effect relationship between traffic related air pollutants in ambient air and induction (incidence) of asthma and sensitization to allergens. The questionnaire consists of two separate parts. In Part A, you will be asked to comment on the completeness and structure of the causal diagram illustrating scientists¿ current
understanding of the cause¿effect relationship. In Part B, you will be asked to express your confidence in scientists¿ ability to predict the magnitude of a variety of proposed or potential associations.
2010
The aim of this report is to describe the ways to raise public participation and awareness of environmental health issues. It includes: (1) science-policy communications and stakeholder engagement; (2) network portal; (3) knowledge evaluation on hot topics within environmental health fields; and (4) decision support tools for practitioners. In addition, this report summarizes the main outcome from the HENVINET final conference. It includes: (1) complexity in environment and health; (2) tools for practice; (3) communication strategies; and (4) exchange of knowledge and results with related projects and research initiatives.
2010
HENVINET. Second annual review of research and best practice. NILU OR
The aim of this report is to present an overview of the framework for assessment of knowledge quality and identification of knowledge gaps within the HENVINET project. The focus is on four priority health end points as defined in the European Health Action Plan (EHAP); asthma and allergies, cancer, neurodevelopmental disorders and endocrine disruptors. This report is structured into two parts, where Part A introduces the HENVINET methodology, and Part B gives an example of how it is implemented through the different steps. The available results are furthermore presented in the Annexes.
2010
2021
Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model
(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures better than 2D cultures. This study aims to compare cytotoxic and genotoxic responses induced by titanium dioxide (TiO2), silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) in 2D monolayer and 3D spheroid cultures of HepG2 human liver cells. (2) NPs were characterized by electron microscopy, dynamic light scattering, laser Doppler anemometry, UV-vis spectroscopy and mass spectrometry. Cytotoxicity was investigated by the alamarBlue assay and confocal microscopy in HepG2 monolayer and spheroid cultures after 24 h of NP exposure. DNA damage (strand breaks and oxidized base lesions) was measured by the comet assay. (3) Ag-NPs were aggregated at 24 h, and a substantial part of the ZnO-NPs was dissolved in culture medium. Ag-NPs induced stronger cytotoxicity in 2D cultures (EC50 3.8 µg/cm2) than in 3D cultures (EC50 > 30 µg/cm2), and ZnO-NPs induced cytotoxicity to a similar extent in both models (EC50 10.1–16.2 µg/cm2). Ag- and ZnO-NPs showed a concentration-dependent genotoxic effect, but the effect was not statistically significant. TiO2-NPs showed no toxicity (EC50 > 75 µg/cm2). (4) This study shows that the HepG2 spheroid model is a promising advanced in vitro model for toxicity assessment of NPs.
MDPI
2020
2000
2008
2007
2007
2014
2004