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Copper oxide nanoparticles (CuO NPs) are increasingly used in various industry sectors. Moreover, medical application of CuO NPs as antimicrobials also contributes to human exposure. Their toxicity, including toxicity to the immune system and blood, raises concerns, while information on their immunotoxicity is still very limited. The aim of our work was to evaluate the effects of CuO NPs (number concentration 1.40×106 particles/cm3, geometric mean diameter 20.4 nm) on immune/inflammatory response and antioxidant defense in mice exposed to 32.5 µg CuO/m3 continuously for 6 weeks. After six weeks of CuO NP inhalation, the content of copper in lungs and liver was significantly increased, while in kidneys, spleen, brain, and blood it was similar in exposed and control mice. Inhalation of CuO NPs caused a significant increase in proliferative response of T-lymphocytes after mitogenic stimulation and basal proliferative activity of splenocytes. CuO NPs significantly induced the production of IL-12p70, Th1-cytokine IFN-γ and Th2-cytokines IL-4, IL-5. Levels of TNF-α and IL-6 remained unchanged. Immune assays showed significantly suppressed phagocytic activity of granulocytes and slightly decreased respiratory burst. No significant differences in phagocytosis of monocytes were recorded. The percentage of CD3+, CD3+CD4+, CD3+CD8+, and CD3-CD19+ cell subsets in spleen, thymus, and lymph nodes did not differ between exposed and control animals. No changes in hematological parameters were found between the CuO NP exposed and control groups. The overall antioxidant protection status of the organism was expressed by evaluation of GSH and GSSG concentrations in blood samples. The experimental group exposed to CuO NPs showed a significant decrease in GSH concentration in comparison to the control group. In summary, our results indicate that sub-chronic inhalation of CuO NPs can cause undesired modulation of the immune response. Stimulation of adaptive immunity was indicated by activation of proliferation and secretion functions of lymphocytes. CuO NPs elicited pro-activation state of Th1 and Th2 lymphocytes in exposed mice. Innate immunity was affected by impaired phagocytic activity of granulocytes. Reduced glutathione was significantly decreased in mice exposed to CuO NPs.
Frontiers Media S.A.
2022
2019
2019
Copernicus Atmosphere Monitoring Servicice
2024
Copernicus Atmosphere Monitoring Service
2023
Copernicus Atmosphere Monitoring Service
2022
Copernicus Atmosphere Monitoring Service
2021
Copernicus Atmosphere Monitoring Service
2020
Copernicus Atmosphere Monitoring Service
2019
2019
2019
2017
2009
Coordinated lidar observations of Saharan dust over Europe in the frame of EARLINET-ASOS project during CALIPSO overpasses: a strong dust case study analysis with modeling support. Proceedings of the SPIE, 7479
2009
2003
2007
2010
2004
Cooling of the wintertime Arctic stratosphere induced by the western Pacific teleconnection pattern. NILU PP
2010
Cooling of the wintertime Arctic stratosphere induced by the western Pacific teleconnection pattern. NILU PP
2010
Cooling of the wintertime Arctic stratosphere induced by the western Pacific teleconnection pattern.
2010
This report presents the ICP Materials database for the period October 2020 to December 2021. It includes environmental data from the ICP Materials trend exposure programme for 2020 - 2021 and, in addition, data for temperature, relative
humidity, and precipitation amount back to the end of the previous annual exposure programme in October/November 2018. The database consists of meteorological data (T, RH and precipitation amount) and pollution data: Gas concentrations, amounts of ions in precipitation, particle concentrations and amounts of particle deposition.
NILU
2023
This report presents the ICP Materials database for the period October 2017 - November 2018. It includes environmental data from the ICP Materials trend exposure programme for 2017 - 2018, and in addition, data for temperature, relative humidity, and precipitation amount back to the end of the previous annual exposure porgramme in October/November 2015. The database consists of meteorological data (T, RH and precipitation amount) and pollution data, as gas concentrations, amounts of ions in precipitation, particle concentrations and amounts of particle deposition.
NILU
2020