Fant 9864 publikasjoner. Viser side 368 av 395:
2023
2023
A flexible algorithm for network design based on information theory
A novel method for atmospheric network design is presented, which is based on information theory. The method does not require calculation of the posterior uncertainty (or uncertainty reduction) and is therefore computationally more efficient than methods that require this. The algorithm is demonstrated in two examples: the first looks at designing a network for monitoring CH4 sources using observations of the stable carbon isotope ratio in CH4 (δ13C), and the second looks at designing a network for monitoring fossil fuel emissions of CO2 using observations of the radiocarbon isotope ratio in CO2 (Δ14CO2).
2023
2023
2023
2023
2023
2023
Plastic pollution (including microplastics) has been reported in a variety of biotic and abiotic compartments across the circumpolar Arctic. Due to their environmental ubiquity, there is a need to understand not only the fate and transport of physical plastic particles, but also the fate and transport of additive chemicals associated with plastic pollution. Further, there is a fundamental research gap in understanding long-range transport of chemical additives to the Arctic via plastics as well as their behavior under environmentally relevant Arctic conditions. Here, we comment on the state of the science of plastic as carriers of chemical additives to the Arctic, and highlight research priorities going forward. We suggest further research on the transport pathways of chemical additives via plastics from both distant and local sources and laboratory experiments to investigate chemical behavior of plastic additives under Arctic conditions, including leaching, uptake, and bioaccumulation. Ultimately, chemical additives need to be included in strategic monitoring efforts to fully understand the contaminant burden of plastic pollution in Arctic ecosystems.
2023
Skogens helsetilstand i Norge. Resultater fra skogskadeovervåkingen i 2021
Skogens helsetilstand påvirkes i stor grad av klima og værforhold, enten direkte ved tørke, frost og vind, eller indirekte ved at klimaet påvirker omfanget av soppsykdommer og insektangrep. Klimaendringene og den forventede økningen i klimarelaterte skogskader gir store utfordringer for forvaltningen av framtidas skogressurser. Det samme gjør invaderende skadegjørere, både allerede etablerte arter og nye som kan komme til Norge i nær framtid. I denne rapporten presenteres resultater fra skogskadeovervåkingen i Norge i 2021 og trender over tid for følgende temaer:
(i) Landsrepresentativ skogovervåking;
(ii) Skogøkologiske analyser og målinger av luftkjemi på de intensive overvåkingsflatene;
(iii) Overvåking av bjørkemålere i Troms og Finnmark;
(iv) Barkbilleovervåkingen 2021 og mulig overgang til to generasjoner;
(v) Asiatisk askepraktbille – en dørstokkart?
(vi) Overvåking av askeskuddsyke;
(vii) Andre spesielle skogskader i 2021.
NIBIO
2023
2023
2023
Nasjonalt veikart for CO2M/CO2MVS
På vegne av Norsk Romsenter har NILU – Norsk institutt for luftforskning og CICERO Senter for klimaforskning utarbeidet et veikart for hvordan Norge kan nyttiggjøre seg data fra CO2 Monitoring-satellittene (CO2M) og tjenesten CO2-emissions Monitoring and Verification Support Capacity (CO2MVS) i forvaltning, forskningsmiljøer og næringsliv. Veikartet avslutter med anbefalinger for veien videre for Norge vedrørende CO2M og CO2MVS.
NILU
2023
Nanomedicine and epigenetics: New alliances to increase the odds in pancreatic cancer survival
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers worldwide, primarily due to its robust desmoplastic stroma and immunosuppressive tumor microenvironment (TME), which facilitate tumor progression and metastasis. In addition, fibrous tissue leads to sparse vasculature, high interstitial fluid pressure, and hypoxia, thereby hindering effective systemic drug delivery and immune cell infiltration. Thus, remodeling the TME to enhance tumor perfusion, increase drug retention, and reverse immunosuppression has become a key therapeutic strategy. In recent years, targeting epigenetic pathways has emerged as a promising approach to overcome tumor immunosuppression and cancer progression. Moreover, the progress in nanotechnology has provided new opportunities for enhancing the efficacy of conventional and epigenetic drugs. Nano-based drug delivery systems (NDDSs) offer several advantages, including improved drug pharmacokinetics, enhanced tumor penetration, and reduced systemic toxicity. Smart NDDSs enable precise targeting of stromal components and augment the effectiveness of immunotherapy through multiple drug delivery options. This review offers an overview of the latest nano-based approaches developed to achieve superior therapeutic efficacy and overcome drug resistance. We specifically focus on the TME and epigenetic-targeted therapies in the context of PDAC, discussing the advantages and limitations of current strategies while highlighting promising new developments. By emphasizing the immense potential of NDDSs in improving therapeutic outcomes in PDAC, our review paves the way for future research in this rapidly evolving field.
Elsevier
2023