Fant 9998 publikasjoner. Viser side 367 av 400:
2021
<p><i>Background</i>: Human biomonitoring studies have demonstrated decreasing concentrations of many persistent organic pollutants (POPs) in years after emission peaks.</p> <p><i>Objectives</i>: To describe time trends of POPs in blood using four cross-sectional samples of 30 year olds from Tromsø, Norway across 1986–2007, and to compare the measured concentrations of polychlorinated biphenyl 153 (PCB-153) to model-estimated values. A second objective was to compare the repeated cross-sectional time trends with those observed in our previous longitudinal study using repeated individual measurements in older men from the same surveys.</p> <p><i>Methods</i>: Serum from 45 persons aged 30 years in each of the following years: 1986, 1994, 2001, and 2007 was analyzed for 14 POPs. Further, predicted concentrations of PCB-153 in each sampling year were derived using the emission-based CoZMoMAN model.</p> <p><i>Results</i>: The median decreases in summed serum POP concentrations (lipid-adjusted) in 1994, 2001, and 2007 relative to 1986 were − 71%, − 81%, and − 86% for women and − 65%, − 77%, and − 87% for men, respectively. The overall time trend in predicted PCB-153 concentrations demonstrated agreement with the observed trend although model predictions were higher than the measured concentrations at all time points. Compared to our previous longitudinal study of repeated individual measurements in older men, similar although more prominent declines were observed in the younger cross-sectional samples.</p> <p><i>Discussion</i>: Observed declines in serum concentrations from 1986 to 2007 were substantial for legacy POPs in men and women at reproductive ages in Northern Norway and are generally consistent with previous longitudinal biomonitoring efforts in the study population. The measured concentrations and observed declines likely reflect a combination of recent and historic exposures. Small differences in time trends observed between the studies could be attributed to different study designs (i.e. the chosen age group or sex and cross-sectional versus repeated individual measurement sampling).</p>
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2023
Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects of TiO2 NPs using a whole-body inhalation chamber model are rare. In this study, the profile of lymphocyte markers, functional immunoassays, and antioxidant defense markers were analyzed to evaluate the potential adverse effects of seven-week inhalation exposure to two different concentrations of TiO2 NPs (0.00167 and 0.1308 mg TiO2/m3) in mice. A dose-dependent effect of TiO2 NPs on innate immunity was evident in the form of stimulated phagocytic activity of monocytes in low-dose mice and suppressed secretory function of monocytes (IL-18) in high-dose animals. The effect of TiO2 NPs on adaptive immunity, manifested in the spleen by a decrease in the percentage of T-cells, a reduction in T-helper cells, and a dose-dependent decrease in lymphocyte cytokine production, may indicate immunosuppression in exposed mice. The dose-dependent increase in GSH concentration and GSH/GSSG ratio in whole blood demonstrated stimulated antioxidant defense against oxidative stress induced by TiO2 NP exposure.
2023
2019
TK-4103C/D Mongstad. Spredningsberegninger. NILU OR
NILU - Norsk institutt for luftforskning har på oppdrag fra Statoil Petroleum gjort spredningsberegninger av utslipp av SO2 til luft fra skorstein TK-4103C/D på Mongstad.
Beregningene gjøres som forarbeid i forbindelse med planlagte arbeider og oppgraderinger ved raffineriet (modifikasjon M1: 42647634 ¿ avgassutfordringer fra SRU RS14). Resultatene sammenlignes med gjeldende akseptkriterier, deriblant ACGIH TLV-STEL (American Conference of Governmental Industrial Hygiene som har korttids grenseverdi lik 0,65 mg/m3). Konklusjonen er at de fleste beregningspunktene viser høyere maksimumskonsentrasjon enn ACGIH-standarden. Forslag til avbøtende tiltak og mulige forholdsregler er gitt.
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