Fant 9758 publikasjoner. Viser side 109 av 391:
2017
Preliminary assessments under the 4th daughter directive. ETC/ACC Technical paper 2007/10
2007
Preliminary assessment report on the spatial mapping of air quality trends for Europe. ETC/ACC Tecnical paper, 2008/3
2008
2003
2014
2012
2005
2019
2008
2019
The blood enzyme glutamate-oxaloacetate transaminase (GOT) has been postulated as an effective therapeutic to protect the brain during stroke. To demonstrate its potential clinical utility, a new human recombinant form of GOT (rGOT) was produced for medical use.
We tested the pharmacokinetics and evaluated the protective efficacy of rGOT in rodent and non-human primate models that reflected clinical stroke conditions.
We found that continuous intravenous administration of rGOT within the first 8 h after ischemic onset significantly reduced the infarct size in both severe (30%) and mild lesions (48%). Cerebrospinal fluid and proteomics analysis, in combination with positron emission tomography imaging, indicated that rGOT can reach the brain and induce cytoprotective autophagy and induce local protection by alleviating neuronal apoptosis.
Our results suggest that rGOT can be safely used immediately in patients suspected of having a stroke. This study requires further validation in clinical stroke populations.
2024
2014
2012
2023
2024
2020
Potential improvements on benzo(a)pyrene (BaP) mapping. ETC/ACM Technical Paper, 2016/3
2016
Potential environmental impact of bromoform from Asparagopsis farming in Australia
To mitigate the rumen enteric methane (CH4) produced by ruminant livestock, Asparagopsis taxiformis is proposed as an additive to ruminant feed. During the cultivation of Asparagopsis taxiformis in the sea or in terrestrially based systems, this macroalgae, like most seaweeds and phytoplankton, produces a large amount of bromoform (CHBr3), which contributes to ozone depletion once released into the atmosphere. In this study, we focus on the impact of CHBr3 on the stratospheric ozone layer resulting from potential emissions from proposed Asparagopsis cultivation in Australia. The impact is assessed by weighting the emissions of CHBr3 with its ozone depletion potential (ODP), which is traditionally defined for long-lived halocarbons but has also been applied to very short-lived substances (VSLSs). An annual yield of ∼3.5 × 104 Mg dry weight is required to meet the needs of 50 % of the beef feedlot and dairy cattle in Australia. Our study shows that the intensity and impact of CHBr3 emissions vary, depending on location and cultivation scenarios. Of the proposed locations, tropical farms near the Darwin region are associated with the largest CHBr3 ODP values. However, farming of Asparagopsis using either ocean or terrestrial cultivation systems at any of the proposed locations does not have the potential to significantly impact the ozone layer. Even if all Asparagopsis farming were performed in Darwin, the CHBr3 emitted into the atmosphere would amount to less than 0.02 % of the global ODP-weighted emissions. The impact of remaining farming scenarios is also relatively small even if the intended annual yield in Darwin is scaled by a factor of 30 to meet the global requirements, which will increase the global ODP-weighted emissions up to ∼0.5 %.
2022
Arctic-breeding geese acquire resources for egg production from overwintering and breeding grounds, where pollutant exposure may differ. We investigated the effect of migration strategy on pollutant occurrence of lipophilic polychlorinated biphenyls (PCBs) and protein-associated poly- and perfluoroalkyl substances (PFASs) and mercury (Hg) in eggs of herbivorous barnacle geese (Branta leucopsis) from an island colony on Svalbard. Stable isotopes (δ13C and δ15N) in eggs and vegetation collected along the migration route were similar. Pollutant concentrations in eggs were low, reflecting their terrestrial diet (∑PCB = 1.23 ± 0.80 ng/g ww; ∑PFAS = 1.21 ± 2.97 ng/g ww; Hg = 20.17 ± 7.52 ng/g dw). PCB concentrations in eggs increased with later hatch date, independently of lipid content which also increased over time. Some females may remobilize and transfer more PCBs to their eggs, by delaying migration several weeks, relying on more polluted and stored resources, or being in poor body condition when arriving at the breeding grounds. PFAS and Hg occurrence in eggs did not change throughout the breeding season, suggesting migration has a greater effect on lipophilic pollutants. Pollutant exposure during offspring production in Arctic-breeding migrants may result in different profiles, with effects becoming more apparent with increasing trophic levels.
2019
2011
2007