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2020
Epigenetics in breast cancer therapy—New strategies and future nanomedicine perspectives
Epigenetic dysregulation has been recognized as a critical factor contributing to the development of resistance against standard chemotherapy and to breast cancer progression via epithelial-to-mesenchymal transition. Although the efficacy of the first-generation epigenetic drugs (epi-drugs) in solid tumor management has been disappointing, there is an increasing body of evidence showing that epigenome modulation, in synergy with other therapeutic approaches, could play an important role in cancer treatment, reversing acquired therapy resistance. However, the epigenetic therapy of solid malignancies is not straightforward. The emergence of nanotechnologies applied to medicine has brought new opportunities to advance the targeted delivery of epi-drugs while improving their stability and solubility, and minimizing off-target effects. Furthermore, the omics technologies, as powerful molecular epidemiology screening tools, enable new diagnostic and prognostic epigenetic biomarker identification, allowing for patient stratification and tailored management. In combination with new-generation epi-drugs, nanomedicine can help to overcome low therapeutic efficacy in treatment-resistant tumors. This review provides an overview of ongoing clinical trials focusing on combination therapies employing epi-drugs for breast cancer treatment and summarizes the latest nano-based targeted delivery approaches for epi-drugs. Moreover, it highlights the current limitations and obstacles associated with applying these experimental strategies in the clinics.
2020
MetVed v.2.0. Improvement and update of the MetVed emission model for residential wood combustion
This report presents the update of the MetVed-model (Grythe et al., 2019). Among the updates are new emission factors and several new species that include climate gases (CO2, CH4 and N2O). There is now a new parameter that describes the emission altitude and a new and improved time variation. Activity data has been updated to the most recent year (2019), which also has required updates to the model and model input variables. The largest update has been the holiday cabin emission module, which is an entirely new addition. Emissions from cabins differ in several ways from residential emissions. The most notable difference is that cabins are spread over more rural areas and are more dispersed than the residential dwellings. The model differentiates alpine and coastal cabins, which is an important distinction as a high density of cabins exists along the coast and they are mainly used during summer.
NILU
2020
2020
Validation of the TROPOspheric Monitoring Instrument (TROPOMI) surface UV radiation product
The TROPOspheric Monitoring Instrument (TROPOMI) onboard the Sentinel-5 Precursor (S5P) satellite was launched on 13 October 2017 to provide the atmospheric composition for atmosphere and climate research. The S5P is a Sun-synchronous polar-orbiting satellite providing global daily coverage. The TROPOMI swath is 2600 km wide, and the ground resolution for most data products is 7.2×3.5 km2 (5.6×3.5 km2 since 6 August 2019) at nadir. The Finnish Meteorological Institute (FMI) is responsible for the development of the TROPOMI UV algorithm and the processing of the TROPOMI surface ultraviolet (UV) radiation product which includes 36 UV parameters in total. Ground-based data from 25 sites located in arctic, subarctic, temperate, equatorial and Antarctic areas were used for validation of the TROPOMI overpass irradiance at 305, 310, 324 and 380 nm, overpass erythemally weighted dose rate/UV index, and erythemally weighted daily dose for the period from 1 January 2018 to 31 August 2019. The validation results showed that for most sites 60 %–80 % of TROPOMI data was within ±20 % of ground-based data for snow-free surface conditions. The median relative differences to ground-based measurements of TROPOMI snow-free surface daily doses were within ±10 % and ±5 % at two-thirds and at half of the sites, respectively. At several sites more than 90 % of cloud-free TROPOMI data was within ±20 % of ground-based measurements. Generally median relative differences between TROPOMI data and ground-based measurements were a little biased towards negative values (i.e. satellite data < ground-based measurement), but at high latitudes where non-homogeneous topography and albedo or snow conditions occurred, the negative bias was exceptionally high: from −30 % to −65 %. Positive biases of 10 %–15 % were also found for mountainous sites due to challenging topography. The TROPOMI surface UV radiation product includes quality flags to detect increased uncertainties in the data due to heterogeneous surface albedo and rough terrain, which can be used to filter the data retrieved under challenging conditions.
2020
Measurements of solar ultraviolet radiation (UVR) performed between January and June 2020 at 10 Arctic and subarctic locations are compared with historical observations. Differences between 2020 and prior years are also assessed with total ozone column and UVR data from satellites. Erythemal (sunburning) UVR is quantified with the UV Index (UVI) derived from these measurements. UVI data show unprecedently large anomalies, occurring mostly between early March and mid‐April 2020. For several days, UVIs observed in 2020 exceeded measurements of previous years by up to 140%. Historical means were surpassed by more than six standard deviations at several locations in the Arctic. In northern Canada, the average UVI for March was about 75% larger than usual. UVIs in April 2020 were elevated on average by about 25% at all sites. However, absolute anomalies remained below 3.0 UVI units because the enhancements occurred during times when the solar elevation was still low.
2020
Thousands of per- and polyfluoroalkyl substances (PFAS) exist in the environment and pose a potential health hazard. Suspect and nontarget screening with liquid chromatography (LC)–high-resolution tandem mass spectrometry (HRMS/MS) can be used for comprehensive characterization of PFAS. To date, no automated open source PFAS data analysis software exists to mine these extensive data sets. We introduce FluoroMatch, which automates file conversion, chromatographic peak picking, blank feature filtering, PFAS annotation based on precursor and fragment masses, and annotation ranking. The software library currently contains ∼7 000 PFAS fragmentation patterns based on rules derived from standards and literature, and the software automates a process for users to add additional compounds. The use of intelligent data-acquisition methods (iterative exclusion) nearly doubled the number of annotations. The software application is demonstrated by characterizing PFAS in landfill leachate as well as in leachate foam generated to concentrate the compounds for remediation purposes. FluoroMatch had wide coverage, returning 27 PFAS annotations for landfill leachate samples, explaining 71% of the all-ion fragmentation (CF2)n related fragments. By improving the throughput and coverage of PFAS annotation, FluoroMatch will accelerate the discovery of PFAS posing significant human risk.
2020
Biomass burning related aerosol episodes are becoming a serious threat to the radiative balance of the Arctic region. Since early July 2017 intense wildfires were recorded between August and September in Canada and Greenland, covering an area up to 4674 km2 in size. This paper describes the impact of these biomass burning (BB) events measured over Svalbard, using an ensemble of ground-based, columnar, and vertically-resolved techniques. BB influenced the aerosol chemistry via nitrates and oxalates, which exhibited an increase in their concentrations in all of size fractions, indicating the BB origin of particles. The absorption coefficient data (530 nm) at ground reached values up to 0.6 Mm–1, highlighting the impact of these BB events when compared to average Arctic background values, which do not exceed 0.05 Mm–1. The absorption behavior is fundamental as implies a subsequent atmospheric heating. At the same time, the AERONET Aerosol Optical Depth (AOD) data showed high values at stations located close to or in Canada (AOD over 2.0). Similarly, increased values of AODs were then observed in Svalbard, e.g., in Hornsund (daily average AODs exceeded 0.14 and reached hourly values up to 0.5). Elevated values of AODs were then registered in Sodankylä and Andenes (daily average AODs exceeding 0.150) a few days after the Svalbard observation of the event highlighting the BB columnar magnitude, which is crucial for the radiative impact. All the reported data suggest to rank the summer 2017 plume of aerosols as one of the biggest atmosphere related environmental problems over Svalbard region in last 10 years
2020
2020
Estimation of damage cost to building facades per kilo emission of air pollution in Norway
This work reports marginal damage costs to façades due to air pollution exposure estimated “bottom up,” for Norway and Oslo (Norway) by the use of exposure response functions (ERFs) and impact pathway analysis from the emission to the deteriorating impact. The aim of the work was to supply cost estimates that could be compared with reported damage costs to health, agriculture, and ecosystems, and that could be used in cost-benefit analysis by environmental authorities. The marginal damage costs for cleaning, repair, and in total (cleaning + repair) were found to be, in Norway: eight, two, and 10, respectively, and for a traffic situation in Oslo: 50 (77), 50 (28), and 100 (105), (×/÷ 2.5) Euro/kg emission of PM10, SO2, and NO2 in total. For Oslo, the values represent a recorded façade materials inventory for 17–18th century buildings, and in the brackets the same façade inventory as for Norway. In total, 5–10% of the marginal damage cost was found to be due to NO2. The total marginal cost was found to be shared about equally between the impact of PM10 and SO2 in Norway (50 and 42% of the impact) and for the 17–18th century buildings in Oslo (45% and 49% of the impact), but for a similar façade materials inventory in Oslo as Norway, the total marginal cost due to PM10 was about two-thirds and that due to SO2 about one-third of the total, with about 5% of the cost still being due to NO2. The division of the costs between the separate pollutant influences on the cleaning and repair was, however, found to be significantly different in Norway and Oslo. In Norway, about 60% of the marginal cleaning cost was found to be due to PM10, 30% due to SO2, and 10% due to NO2. In Oslo, about 85% of the marginal cleaning costs were found to be due to PM10, 10% due to SO2, and 5% due to NO2. For the marginal repair cost, the opposite situation was found, in both Norway and Oslo, with 80–90% of the cost being due to SO2, 5–10% being due to PM10, and 5–10% due to NO2. As other factors than air pollution deteriorates façades and influences maintenance decisions, the expenses that can be attributed to the air pollution could be significantly lower.
2020
Regionalized environmental impacts of construction machinery
PURPOSE:
This study aims to establish a regionalized environmental impact assessment of construction machinery equipped with diesel engines certified by the European emission standard Stage V, and operated in cold climatic zones in Europe.
METHOD:
The study quantifies potential environmental impacts associated with construction machinery over the entire lifecycle, from extraction of materials to the end-of-life. For the operation phase, a meso-level emission accounting method is applied to quantify tailpipe emissions for certain subcategories of construction machinery. This is achieved by determining the operational efficiency of each machine in terms of effective hours. The quantified emission data are then adjusted based on engine deterioration models to estimate the rate of increase in emissions throughout the lifetime of each machine. Finally, the CML impact assessment method is applied to inventory data to quantify potential environmental impacts.
RESULTS:
The study shows that tailpipe emissions, which largely depend on an engine’s fuel consumption, had the largest contribution to environmental impacts in most impact categories. At the same time, there was a positive correlation between the operation weight and the impacts of the machinery. Also, machinery with similar operation weight had relatively similar impact patterns due to similar driving factors and dependencies. In addition, network, sensitivity, and uncertainty analyses were performed to quantify the source of impacts and validate the robustness of the study. Results of the sensitivity analysis showed that the responsiveness of the studied systems is very sensitive to changes in the amount of fuel consumption. In addition, the uncertainty results showed that the domain of uncertainty increased as the operation weight subcategory of machinery increased.
CONCLUSION:
This study extends previous work on the life cycle assessment (LCA) of construction machinery, and the methodology developed provides a basis for future extension and improvement in this field. The use of effective hours as the unit of operational efficiency helps to resolve uncertainties linked to lifetime and annual operation hours. Also, the obtained results can be of use for decision support and for assessing the impacts of transition from fossil fuels to alternative fuel types.
2020
Use of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress has been made with establishing robust protocols for skin, airway (lung) and liver tissue equivalents. In light of these advancements, a “Use of 3D Tissues in Genotoxicity Testing” working group (WG) met at the 7th IWGT meeting in Tokyo in November 2017 to discuss progress with these models and how they may fit into a genotoxicity testing strategy. The workshop demonstrated that skin models have reached an advanced state of validation following over 10 years of development, while liver and airway model-based genotoxicity assays show promise but are at an early stage of development. Further effort in liver and airway model-based assays is needed to address the lack of coverage of the three main endpoints of genotoxicity (mutagenicity, clastogenicity and aneugenicity), and information on metabolic competence. The IWGT WG believes that the 3D skin comet and micronucleus assays are now sufficiently validated to undergo an independent peer review of the validation study, followed by development of individual OECD Test Guidelines.
2020
Nanotechnology has enabled the discovery of a multitude of novel materials exhibiting unique physicochemical (PChem) properties compared to their bulk analogues. These properties have led to a rapidly increasing range of commercial applications; this, however, may come at a cost, if an association to long-term health and environmental risks is discovered or even just perceived. Many nanomaterials (NMs) have not yet had their potential adverse biological effects fully assessed, due to costs and time constraints associated with the experimental assessment, frequently involving animals. Here, the available NM libraries are analyzed for their suitability for integration with novel nanoinformatics approaches and for the development of NM specific Integrated Approaches to Testing and Assessment (IATA) for human and environmental risk assessment, all within the NanoSolveIT cloud-platform. These established and well-characterized NM libraries (e.g. NanoMILE, NanoSolutions, NANoREG, NanoFASE, caLIBRAte, NanoTEST and the Nanomaterial Registry (>2000 NMs)) contain physicochemical characterization data as well as data for several relevant biological endpoints, assessed in part using harmonized Organisation for Economic Co-operation and Development (OECD) methods and test guidelines. Integration of such extensive NM information sources with the latest nanoinformatics methods will allow NanoSolveIT to model the relationships between NM structure (morphology), properties and their adverse effects and to predict the effects of other NMs for which less data is available. The project specifically addresses the needs of regulatory agencies and industry to effectively and rapidly evaluate the exposure, NM hazard and risk from nanomaterials and nano-enabled products, enabling implementation of computational ‘safe-by-design’ approaches to facilitate NM commercialization.
2020
An assessment of the contribution of air pollution to the weathering of limestone heritage in Malta
Malta is known for its limestone megalithic temples of which many are inscribed on the UNESCO World Heritage List. A variation of this limestone was historically, and until very few years ago, a primary building material in Malta. The temples are subject to various environmental influences which until recently have led to several collapses due in part to serious stone surface and infill loss. As a protection measure, open-sided shelters have been built over three of these temples. This work assesses the degrading influence of air pollution (nitrogen dioxide, ozone, particle matter, sulfur dioxide, and acidity in rain) on the temples, in combination and comparison with the influence of other environmental factors (relative humidity, temperature, precipitation, moisture, sea salt, wind) and in this respect evaluates the potential protective effect of the shelters. The variation in air pollution weathering of limestone exposed outdoor in Malta was calculated by exposure–response functions from the ICP-materials programme and compared with measured values, and its contribution to the deterioration of the temples was evaluated. The difference between urban and rural locations in Malta, in the first year of atmospheric chemical weathering of limestone due to air pollution, was found to be about one micrometer loss of stone surface. This is probably less than the annual variations due to the influence of natural climatic factors, and small compared to the present annual variations in continental Europe. The deposition of sea salt and presence of salts on and in the limestone megaliths and changes in salt-crystallization events due to relative humidity fluctuations, inside and outside the shelters, will account for more of the variations in the first year of weathering of Globigerina limestone than variations in air pollution. The deterioration will also be related to temperature (including condensation events), wind parameters and rainfall, as well as ground water replenished from areas beyond the shelter.
2020
Satellite validation strategy assessments based on the AROMAT campaigns
The Airborne ROmanian Measurements of Aerosols and Trace gases (AROMAT) campaigns took place in Romania in September 2014 and August 2015. They focused on two sites: the Bucharest urban area and large power plants in the Jiu Valley. The main objectives of the campaigns were to test recently developed airborne observation systems dedicated to air quality studies and to verify their applicability for the validation of space-borne atmospheric missions such as the TROPOspheric Monitoring Instrument (TROPOMI)/Sentinel-5 Precursor (S5P). We present the AROMAT campaigns from the perspective of findings related to the validation of tropospheric NO2, SO2, and H2CO. We also quantify the emissions of NOx and SO2 at both measurement sites.
We show that tropospheric NO2 vertical column density (VCD) measurements using airborne mapping instruments are well suited for satellite validation in principle. The signal-to-noise ratio of the airborne NO2 measurements is an order of magnitude higher than its space-borne counterpart when the airborne measurements are averaged at the TROPOMI pixel scale. However, we show that the temporal variation of the NO2 VCDs during a flight might be a significant source of comparison error. Considering the random error of the TROPOMI tropospheric NO2 VCD (σ), the dynamic range of the NO2 VCDs field extends from detection limit up to 37 σ (2.6×1016 molec. cm−2) and 29 σ (2×1016 molec. cm−2) for Bucharest and the Jiu Valley, respectively. For both areas, we simulate validation exercises applied to the TROPOMI tropospheric NO2 product. These simulations indicate that a comparison error budget closely matching the TROPOMI optimal target accuracy of 25 % can be obtained by adding NO2 and aerosol profile information to the airborne mapping observations, which constrains the investigated accuracy to within 28 %. In addition to NO2, our study also addresses the measurements of SO2 emissions from power plants in the Jiu Valley and an urban hotspot of H2CO in the centre of Bucharest. For these two species, we conclude that the best validation strategy would consist of deploying ground-based measurement systems at well-identified locations.
2020
Environmental Contaminants in an Urban Fjord, 2019
This programme, “Environmental Contaminants in an Urban Fjord” has covered sampling and analyses of sediment and organisms in a marine food web of the Inner Oslofjord, in addition to samples of blood and eggs from herring gull. The programme also included inputs of pollutants via surface water (storm water), and effluent water and sludge from a sewage treatment plant. The bioaccumulation potential of the contaminants in the Oslo fjord food web was evaluated. The exposure to/accumulation of the contaminants was also assessed in birds. A vast number of chemical parameters have been quantified, in addition to some biological effect parameters in cod, and the report serves as a status description of the concentrations of these chemicals in different compartments of the Inner Oslofjord marine ecosystem.
Norsk institutt for vannforskning (NIVA)
2020
Recent years have seen the increasing inclusion of per-retrieval prognostic (predictive) uncertainty estimates within satellite aerosol optical depth (AOD) data sets, providing users with quantitative tools to assist in optimal use of these data. Prognostic estimates contrast with diagnostic (i.e. relative to some external truth) ones, which are typically obtained using sensitivity and/or validation analyses. Up to now, however, the quality of these uncertainty estimates has not been routinely assessed. This study presents a review of existing prognostic and diagnostic approaches for quantifying uncertainty in satellite AOD retrievals, and presents a general framework to evaluate them, based on the expected statistical properties of ensembles of estimated uncertainties and actual retrieval errors. It is hoped that this framework will be adopted as a complement to existing AOD validation exercises; it is not restricted to AOD and can in principle be applied to other quantities for which a reference validation data set is available. This framework is then applied to assess the uncertainties provided by several satellite data sets (seven over land, five over water), which draw on methods from the empirical to sensitivity analyses to formal error propagation, at 12 Aerosol Robotic Network (AERONET) sites. The AERONET sites are divided into those where it is expected that the techniques will perform well, and those for which some complexity about the site may provide a more severe test. Overall all techniques show some skill in that larger estimated uncertainties are generally associated with larger observed errors, although they are sometimes poorly calibrated (i.e. too small/large in magnitude). No technique uniformly performs best. For powerful formal uncertainty propagation approaches such as Optimal Estimation the results illustrate some of the difficulties in appropriate population of the covariance matrices required by the technique. When the data sets are confronted by a situation strongly counter to the retrieval forward model (e.g. potential mixed land/water surfaces, or aerosol optical properties outside of the family of assumptions), some algorithms fail to provide a retrieval, while others do but with a quantitatively unreliable uncertainty estimate. The discussion suggests paths forward for refinement of these techniques.
2020